After Lorentano, Domenico Pisani took over in 1480, but the Lorentano family returned in 1537. The same year the castle fell into the hands of Barbarossa. the island passed completely into the ottoman empire in 1556.
From 1770-1774 Antiparos was held by the Russians, as was Paros.
In 1794 a gang of Maiots and Cephallonias slaughtered the inhabitants and the island was deserted for a time. In 1821 the island took an active part in the revolution against the Turks.